Arachidonic acid mediates the formation of abundant alpha-helical multimers of alpha-synuclein

The protein alpha-synuclein (αS) self-assembles into toxic beta-sheet aggregates in Parkinson’s disease, while it is proposed that αS forms soluble alpha-helical multimers in healthy neurons. Here, we have made αS multimers in vitro using arachidonic acid (ARA), one of the most abundant fatty acids...

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Detalles Bibliográficos
Autores principales: Iljina, Marija, Tosatto, Laura, Choi, Minee L., Sang, Jason C., Ye, Yu, Hughes, Craig D., Bryant, Clare E., Gandhi, Sonia, Klenerman, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037366/
https://www.ncbi.nlm.nih.gov/pubmed/27671749
http://dx.doi.org/10.1038/srep33928

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037366/
https://www.ncbi.nlm.nih.gov/pubmed/27671749
http://dx.doi.org/10.1038/srep33928

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