Monocytic MKP-1 is a Sensor of the Metabolic Environment and Regulates Function and Phenotypic Fate of Monocyte-Derived Macrophages in Atherosclerosis

Diabetes promotes the S-glutathionylation, inactivation and subsequent degradation of mitogen-activated protein kinase phosphatase 1 (MKP-1) in blood monocytes, and hematopoietic MKP-1-deficiency in atherosclerosis-prone mice accelerates atherosclerotic lesion formation, but the underlying mechanism...

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Detalles Bibliográficos
Autores principales: Kim, Hong Seok, Tavakoli, Sina, Piefer, Leigh Ann, Nguyen, Huynh Nga, Asmis, Reto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037453/
https://www.ncbi.nlm.nih.gov/pubmed/27670844
http://dx.doi.org/10.1038/srep34223

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037453/
https://www.ncbi.nlm.nih.gov/pubmed/27670844
http://dx.doi.org/10.1038/srep34223

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