The structure of a furin-antibody complex explains non-competitive inhibition by steric exclusion of substrate conformers

Proprotein Convertases (PCs) represent highly selective serine proteases that activate their substrates upon proteolytic cleavage. Their inhibition is a promising strategy for the treatment of cancer and infectious diseases. Inhibitory camelid antibodies were developed, targeting the prototypical PC...

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Detalles Bibliográficos
Autores principales: Dahms, Sven O., Creemers, John W. M., Schaub, Yvonne, Bourenkov, Gleb P., Zögg, Thomas, Brandstetter, Hans, Than, Manuel E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037460/
https://www.ncbi.nlm.nih.gov/pubmed/27670069
http://dx.doi.org/10.1038/srep34303

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037460/
https://www.ncbi.nlm.nih.gov/pubmed/27670069
http://dx.doi.org/10.1038/srep34303

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