Interferon alpha inhibits spinal cord synaptic and nociceptive transmission via neuronal-glial interactions

It is well known that interferons (IFNs), such as type-I IFN (IFN-α) and type-II IFN (IFN-γ) are produced by immune cells to elicit antiviral effects. IFNs are also produced by glial cells in the CNS to regulate brain functions. As a proinflammatory cytokine, IFN-γ drives neuropathic pain by inducin...

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Detalles Bibliográficos
Autores principales: Liu, Chien-Cheng, Gao, Yong-Jing, Luo, Hao, Berta, Temugin, Xu, Zhen-Zhong, Ji, Ru-Rong, Tan, Ping-Heng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037469/
https://www.ncbi.nlm.nih.gov/pubmed/27670299
http://dx.doi.org/10.1038/srep34356

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037469/
https://www.ncbi.nlm.nih.gov/pubmed/27670299
http://dx.doi.org/10.1038/srep34356

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