Cargando…

The Dinoflagellate Toxin 20-Methyl Spirolide-G Potently Blocks Skeletal Muscle and Neuronal Nicotinic Acetylcholine Receptors

The cyclic imine toxin 20-methyl spirolide G (20-meSPX-G), produced by the toxigenic dinoflagellate Alexandrium ostenfeldii/Alexandrium peruvianum, has been previously reported to contaminate shellfish in various European coastal locations, as revealed by mouse toxicity bioassay. The aim of the pres...

Descripción completa

Detalles Bibliográficos
Autores principales:	Couesnon, Aurélie, Aráoz, Rómulo, Iorga, Bogdan I., Benoit, Evelyne, Reynaud, Morgane, Servent, Denis, Molgó, Jordi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037475/ https://www.ncbi.nlm.nih.gov/pubmed/27563924 http://dx.doi.org/10.3390/toxins8090249

Ejemplares similares

Prorocentrolide-A from Cultured Prorocentrum lima Dinoflagellates Collected in Japan Blocks Sub-Types of Nicotinic Acetylcholine Receptors
por: Amar, Muriel, et al.
Publicado: (2018)

Synthetic Pinnatoxins A and G Reversibly Block Mouse Skeletal Neuromuscular Transmission In Vivo and In Vitro
por: Benoit, Evelyne, et al.
Publicado: (2019)

Identification of Novel Gymnodimines and Spirolides from the Marine Dinoflagellate Alexandrium ostenfeldii
por: Zurhelle, Christian, et al.
Publicado: (2018)

Preferential Entry of Botulinum Neurotoxin A Hc Domain through Intestinal Crypt Cells and Targeting to Cholinergic Neurons of the Mouse Intestine
por: Couesnon, Aurélie, et al.
Publicado: (2012)

Gymnodimine A and 13-desMethyl Spirolide C Alter Intracellular Calcium Levels via Acetylcholine Receptors
por: Nieva, Joyce A., et al.
Publicado: (2020)

Spirolides in Bivalve Mollusk of the Galician (NW Spain) Coast: Interspecific, Spatial, Temporal Variation and Presence of an Isomer of 13-Desmethyl Spirolide C
por: Blanco, Juan, et al.
Publicado: (2022)

Investigations into the Toxicology of Spirolides, a Group of Marine Phycotoxins
por: Munday, Rex, et al.
Publicado: (2011)

Detection of Anatoxin-a and Three Analogs in Anabaena spp. Cultures: New Fluorescence Polarization Assay and Toxin Profile by LC-MS/MS
por: Sanchez, Jon A., et al.
Publicado: (2014)

New Invertebrate Vectors for PST, Spirolides and Okadaic Acid in the North Atlantic
por: Silva, Marisa, et al.
Publicado: (2013)

Ribbon α-Conotoxin KTM Exhibits Potent Inhibition of Nicotinic Acetylcholine Receptors
por: Marquart, Leanna A., et al.
Publicado: (2019)

Structural model of nicotinic acetylcholine receptor isotypes bound to acetylcholine and nicotine
por: Schapira, Matthieu, et al.
Publicado: (2002)

Drosophila nicotinic acetylcholine receptor subunits and their native interactions with insecticidal peptide toxins
por: Korona, Dagmara, et al.
Publicado: (2022)

Characterization of a Novel Conus bandanus Conopeptide Belonging to the M-Superfamily Containing Bromotryptophan
por: Nguyen, Bao, et al.
Publicado: (2014)

Neonicotinoid Binding, Toxicity and Expression of Nicotinic Acetylcholine Receptor Subunits in the Aphid Acyrthosiphon pisum
por: Taillebois, Emiliane, et al.
Publicado: (2014)

Report on the First Detection of Pectenotoxin-2, Spirolide-A and Their Derivatives in French Shellfish
por: Amzil, Zouher, et al.
Publicado: (2007)

Mass Spectrometry-Based Characterization of New Spirolides from Alexandrium ostenfeldii (Dinophyceae)
por: Nieva, Joyce A., et al.
Publicado: (2020)

Delineating the activity of the potent nicotinic acetylcholine receptor agonists (+)-anatoxin-a and (−)-hosieine-A
por: Parker, Holly P., et al.
Publicado: (2022)

The Genetic Basis of Toxin Biosynthesis in Dinoflagellates
por: Verma, Arjun, et al.
Publicado: (2019)

Structure-Function of Neuronal Nicotinic Acetylcholine Receptor Inhibitors Derived From Natural Toxins
por: Ho, Thao N. T., et al.
Publicado: (2020)

Nicotinic acetylcholine receptors and cancer
por: DANG, NINGNING, et al.
Publicado: (2016)

In Silico Modeling of Spirolides and Gymnodimines: Determination of S Configuration at Butenolide Ring Carbon C-4
por: Zurhelle, Christian, et al.
Publicado: (2020)

Membrane-mediated interaction of non-conventional snake three-finger toxins with nicotinic acetylcholine receptors
por: Shenkarev, Zakhar O., et al.
Publicado: (2022)

The Na(V)1.7 Channel Subtype as an Antinociceptive Target for Spider Toxins in Adult Dorsal Root Ganglia Neurons
por: Gonçalves, Tânia C., et al.
Publicado: (2018)

Corrigendum: The Na(V)1.7 Channel Subtype as an Antinociceptive Target for Spider Toxins in Adult Dorsal Root Ganglia Neurons
por: Gonçalves, Tânia C., et al.
Publicado: (2018)

The Oncogenic Functions of Nicotinic Acetylcholine Receptors
por: Zhao, Yue
Publicado: (2016)

Nicotinic acetylcholine receptors modulate osteoclastogenesis
por: Mandl, Peter, et al.
Publicado: (2016)

Neuronal and Extraneuronal Nicotinic Acetylcholine Receptors
por: Zoli, Michele, et al.
Publicado: (2018)

Evolution of vertebrate nicotinic acetylcholine receptors
por: Pedersen, Julia E., et al.
Publicado: (2019)

Nicotinic Acetylcholine Receptors in the Respiratory Tract
por: Hollenhorst, Monika I., et al.
Publicado: (2021)

Nicotinic Acetylcholine Receptors Are Novel Targets of APETx-like Toxins from the Sea Anemone Heteractis magnifica
por: Kalina, Rimma S., et al.
Publicado: (2022)

Ostreolysin A/Pleurotolysin B and Equinatoxins: Structure, Function and Pathophysiological Effects of These Pore-Forming Proteins
por: Frangež, Robert, et al.
Publicado: (2017)

Layer-Specific Modulation of the Prefrontal Cortex by Nicotinic Acetylcholine Receptors
por: Poorthuis, Rogier B., et al.
Publicado: (2013)

Genetic association of toxin production in the dinoflagellate Alexandrium minutum
por: Mary, Lou, et al.
Publicado: (2022)

(−)-Adaline from the Adalia Genus of Ladybirds Is a Potent Antagonist of Insect and Specific Mammalian Nicotinic Acetylcholine Receptors
por: Richards, David P., et al.
Publicado: (2022)

Molecular Recognition of the Neurotransmitter Acetylcholine by an Acetylcholine Binding Protein Reveals Determinants of Binding to Nicotinic Acetylcholine Receptors
por: Olsen, Jeppe A., et al.
Publicado: (2014)

Nicotinic Acetylcholine Receptor (nAChR) Dependent Chorda Tympani Taste Nerve Responses to Nicotine, Ethanol and Acetylcholine
por: Ren, Zuo Jun, et al.
Publicado: (2015)

Pathogenesis of Abdominal Aortic Aneurysms: Role of Nicotine and Nicotinic Acetylcholine Receptors
por: Li, Zong-Zhuang, et al.
Publicado: (2012)

Acetylcholine receptors in the retinas of the α7 nicotinic acetylcholine receptor knockout mouse
por: Smith, Marci L., et al.
Publicado: (2014)

Snake Toxins Labeled by Green Fluorescent Protein or Its Synthetic Chromophore are New Probes for Nicotinic acetylcholine Receptors
por: Kasheverov, Igor E., et al.
Publicado: (2021)

The submembrane machinery for nicotinic acetylcholine receptor clustering
Publicado: (1991)

Cannot write session to /tmp/vufind_sessions/sess_10e05dpccspfb7matplvv01vjd