A New Folding Kinetic Mechanism for Human Transthyretin and the Influence of the Amyloidogenic V30M Mutation

Protein aggregation into insoluble amyloid fibrils is the hallmark of several neurodegenerative diseases, chief among them Alzheimer’s and Parkinson’s. Although caused by different proteins, these pathologies share some basic molecular mechanisms with familial amyloidotic polyneuropathy (FAP), a rar...

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Detalles Bibliográficos
Autores principales: Jesus, Catarina S. H., Almeida, Zaida L., Vaz, Daniela C., Faria, Tiago Q., Brito, Rui M. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037707/
https://www.ncbi.nlm.nih.gov/pubmed/27589730
http://dx.doi.org/10.3390/ijms17091428

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037707/
https://www.ncbi.nlm.nih.gov/pubmed/27589730
http://dx.doi.org/10.3390/ijms17091428

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