A Physiologically Based Pharmacokinetic Model of Isoniazid and Its Application in Individualizing Tuberculosis Chemotherapy

Due to its high early bactericidal activity, isoniazid (INH) plays an essential role in tuberculosis treatment. Genetic polymorphisms of N-acetyltransferase type 2 (NAT2) cause a trimodal distribution of INH pharmacokinetics in slow, intermediate, and fast acetylators. The success of INH-based chemo...

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Detalles Bibliográficos
Autores principales: Cordes, Henrik, Thiel, Christoph, Aschmann, Hélène E., Baier, Vanessa, Blank, Lars M., Kuepfer, Lars
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2016
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038291/
https://www.ncbi.nlm.nih.gov/pubmed/27480867
http://dx.doi.org/10.1128/AAC.00508-16

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038291/
https://www.ncbi.nlm.nih.gov/pubmed/27480867
http://dx.doi.org/10.1128/AAC.00508-16

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