A Novel Drug-Mouse Phenotypic Similarity Method Detects Molecular Determinants of Drug Effects

The molecular mechanisms that translate drug treatment into beneficial and unwanted effects are largely unknown. We present here a novel approach to detect gene-drug and gene-side effect associations based on the phenotypic similarity of drugs and single gene perturbations in mice that account for t...

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Detalles Bibliográficos
Autores principales: Prinz, Jeanette, Vogt, Ingo, Adornetto, Gianluca, Campillos, Mónica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038975/
https://www.ncbi.nlm.nih.gov/pubmed/27673331
http://dx.doi.org/10.1371/journal.pcbi.1005111

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038975/
https://www.ncbi.nlm.nih.gov/pubmed/27673331
http://dx.doi.org/10.1371/journal.pcbi.1005111

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