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A Novel Drug-Mouse Phenotypic Similarity Method Detects Molecular Determinants of Drug Effects
The molecular mechanisms that translate drug treatment into beneficial and unwanted effects are largely unknown. We present here a novel approach to detect gene-drug and gene-side effect associations based on the phenotypic similarity of drugs and single gene perturbations in mice that account for t...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038975/ https://www.ncbi.nlm.nih.gov/pubmed/27673331 http://dx.doi.org/10.1371/journal.pcbi.1005111 |