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Substrate-Assisted Catalysis in Polyketide Reduction Proceeds via a Phenolate Intermediate
SimC7 is a polyketide ketoreductase involved in biosynthesis of the angucyclinone moiety of the gyrase inhibitor simocyclinone D8 (SD8). SimC7, which belongs to the short-chain dehydrogenase/reductase (SDR) superfamily, catalyzes reduction of the C-7 carbonyl of the angucyclinone, and the resulting...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039031/ https://www.ncbi.nlm.nih.gov/pubmed/27617849 http://dx.doi.org/10.1016/j.chembiol.2016.07.018 |