Substrate-Assisted Catalysis in Polyketide Reduction Proceeds via a Phenolate Intermediate

SimC7 is a polyketide ketoreductase involved in biosynthesis of the angucyclinone moiety of the gyrase inhibitor simocyclinone D8 (SD8). SimC7, which belongs to the short-chain dehydrogenase/reductase (SDR) superfamily, catalyzes reduction of the C-7 carbonyl of the angucyclinone, and the resulting...

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Detalles Bibliográficos
Autores principales: Schäfer, Martin, Stevenson, Clare E.M., Wilkinson, Barrie, Lawson, David M., Buttner, Mark J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039031/
https://www.ncbi.nlm.nih.gov/pubmed/27617849
http://dx.doi.org/10.1016/j.chembiol.2016.07.018

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