Cargando…

Large-scale profiling of signalling pathways reveals an asthma specific signature in bronchial smooth muscle cells

BACKGROUND: Bronchial smooth muscle (BSM) cells from asthmatic patients maintain in vitro a distinct hyper-reactive (“primed”) phenotype, characterized by increased release of pro-inflammatory factors and mediators, as well as hyperplasia and/or hypertrophy. This “primed” phenotype helps to understa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Alexandrova, Elena, Nassa, Giovanni, Corleone, Giacomo, Buzdin, Anton, Aliper, Alexander M., Terekhanova, Nadezhda, Shepelin, Denis, Zhavoronkov, Alexander, Tamm, Michael, Milanesi, Luciano, Miglino, Nicola, Weisz, Alessandro, Borger, Pieter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039037/ https://www.ncbi.nlm.nih.gov/pubmed/26863634 http://dx.doi.org/10.18632/oncotarget.7209

Ejemplares similares

Calreticulin Is a Negative Regulator of Bronchial Smooth Muscle Cell Proliferation
por: Miglino, Nicola, et al.
Publicado: (2012)

Signaling pathways activation profiles make better markers of cancer than expression of individual genes
por: Borisov, Nikolay M., et al.
Publicado: (2014)

Combinatorial high-throughput experimental and bioinformatic approach identifies molecular pathways linked with the sensitivity to anticancer target drugs
por: Venkova, Larisa, et al.
Publicado: (2015)

Screening and personalizing nootropic drugs and cognitive modulator regimens in silico
por: Jellen, Leslie C., et al.
Publicado: (2015)

Molecular pathway activation features linked with transition from normal skin to primary and metastatic melanomas in human
por: Shepelin, Denis, et al.
Publicado: (2015)

Asthma and COPD - The C/EBP Connection
por: Miglino, Nicola, et al.
Publicado: (2012)

Pathway activation profiling reveals new insights into Age-related Macular Degeneration and provides avenues for therapeutic interventions
por: Makarev, Evgeny, et al.
Publicado: (2014)

Genetics and epigenetics of aging and longevity
por: Moskalev, Alexey A, et al.
Publicado: (2014)

A role for G-CSF and GM-CSF in nonmyeloid cancers
por: Aliper, Alexander M, et al.
Publicado: (2014)

Interactome analysis of myeloid-derived suppressor cells in murine models of colon and breast cancer
por: Aliper, Alexander M., et al.
Publicado: (2014)

Hypoxia Exerts Dualistic Effects on Inflammatory and Proliferative Responses of Healthy and Asthmatic Primary Human Bronchial Smooth Muscle Cells
por: Keglowich, Laura, et al.
Publicado: (2014)

Signaling pathway activation drift during aging: Hutchinson-Gilford Progeria Syndrome fibroblasts are comparable to normal middle-age and old-age cells
por: Aliper, Alexander M., et al.
Publicado: (2015)

Evaluation of the geroprotective effects of withaferin A in Drosophila melanogaster
por: Koval, Liubov, et al.
Publicado: (2021)

Pathway activation strength is a novel independent prognostic biomarker for cetuximab sensitivity in colorectal cancer patients
por: Zhu, Qingsong, et al.
Publicado: (2015)

Proteolytic Activity Present in House-Dust-Mite Extracts Degrades ENA-78/CXCL5 and Reduces Neutrophil Migration
por: Keglowich, Laura, et al.
Publicado: (2014)

Bronchial smooth muscle cell in asthma: where does it fit?
por: Hassoun, Dorian, et al.
Publicado: (2022)

A method for predicting target drug efficiency in cancer based on the analysis of signaling pathway activation
por: Artemov, Artem, et al.
Publicado: (2015)

The OncoFinder algorithm for minimizing the errors introduced by the high-throughput methods of transcriptome analysis
por: Buzdin, Anton A., et al.
Publicado: (2014)

Airway Smooth Muscle as a Target in Asthma and the Beneficial Effects of Bronchial Thermoplasty
por: Janssen, Luke J.
Publicado: (2012)

Mechanisms underlying the pathogenesis of hyper-contractility of bronchial smooth muscle in allergic asthma
por: Sakai, Hiroyasu, et al.
Publicado: (2017)

Bronchial thermoplasty in asthma: an exploratory histopathological evaluation in distinct asthma endotypes/phenotypes
por: Papakonstantinou, Eleni, et al.
Publicado: (2021)

Host nasopharyngeal transcriptome dataset of a SARS-CoV-2 positive Italian cohort
por: Salvati, Annamaria, et al.
Publicado: (2023)

Author Correction: Host nasopharyngeal transcriptome dataset of a SARS-CoV-2 positive Italian cohort
por: Salvati, Annamaria, et al.
Publicado: (2023)

The Three A’s in Asthma – Airway Smooth Muscle, Airway Remodeling & Angiogenesis
por: Keglowich, L.F, et al.
Publicado: (2015)

Bronchial Smooth Muscle Cells of Asthmatics Promote Angiogenesis through Elevated Secretion of CXC-Chemokines (ENA-78, GRO-α, and IL-8)
por: Keglowich, Laura, et al.
Publicado: (2013)

Bronchial smooth muscle remodeling involves calcium-dependent enhanced mitochondrial biogenesis in asthma
por: Trian, Thomas, et al.
Publicado: (2007)

On Bronchial Asthma
Publicado: (1890)

Asthmatic Bronchial Matrices Determine the Gene Expression and Behavior of Smooth Muscle Cells in a 3D Culture Model
por: Ben Hamouda, Selma, et al.
Publicado: (2021)

The Relationship Between Bronchial Patency and Parameters of ECG Supraventricular Component in Children With Bronchial Asthma
por: Gordina, Alina V., et al.
Publicado: (2020)

The Histone Methyltransferase DOT1L Is a Functional Component of Estrogen Receptor Alpha Signaling in Ovarian Cancer Cells
por: Salvati, Annamaria, et al.
Publicado: (2019)

Neurotrophins in bronchial asthma
por: Renz, Harald
Publicado: (2001)

The Treatment of Bronchial Asthma
Publicado: (1947)

Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells
por: Giurato, Giorgio, et al.
Publicado: (2018)

Retroelement—Linked Transcription Factor Binding Patterns Point to Quickly Developing Molecular Pathways in Human Evolution
por: Nikitin, Daniil, et al.
Publicado: (2019)

Correction: Nikitin, D., et al. Retroelement—Linked Transcription Factor Binding Patterns Point to Quickly Developing Molecular Pathways in Human Evolution. Cells 2019, 8, 130
por: Nikitin, Daniil, et al.
Publicado: (2019)

In search for geroprotectors: in silico screening and in vitro validation of signalome-level mimetics of young healthy state
por: Aliper, Alexander, et al.
Publicado: (2016)

An RGS4-Mediated Phenotypic Switch of Bronchial Smooth Muscle Cells Promotes Fixed Airway Obstruction in Asthma
por: Damera, Gautam, et al.
Publicado: (2012)

GREM, a technique for genome-wide isolation and quantitative analysis of promoter active repeats
por: Buzdin, Anton, et al.
Publicado: (2006)

Metabolic activity of intestinal microflora in patients with bronchial asthma
por: Ivashkin, Vladimir, et al.
Publicado: (2019)

Combination of Antiretroviral Drugs Zidovudine and Efavirenz Impairs Tumor Growths in a Mouse Model of Cancer
por: Schneider, Marcel A., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_v3obtgje9en31sdlq23fu20edh