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AKT-STAT3 Pathway as a Downstream Target of EGFR Signaling to Regulate PD-L1 Expression on NSCLC cells

While cancer development and progression can be controlled by cytotoxic T cells, it is also known that tumor-specific CD8(+)T cells become functionally impaired by acquiring a group of inhibitory receptors known as immune checkpoints. Amongst those, programmed death-1 (PD-1) is one of the most recog...

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Detalles Bibliográficos
Autores principales: Abdelhamed, Sherif, Ogura, Keisuke, Yokoyama, Satoru, Saiki, Ikuo, Hayakawa, Yoshihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039378/
https://www.ncbi.nlm.nih.gov/pubmed/27698894
http://dx.doi.org/10.7150/jca.14713