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Depletion of primary cilia from mature dentate granule cells impairs hippocampus-dependent contextual memory

The primary cilium, a sensory organelle, regulates cell proliferation and neuronal development of dentate granule cells in the hippocampus. However, its role in the function of mature dentate granule cells remains unknown. Here we specifically depleted and disrupted ciliary proteins IFT20 and Kif3A...

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Detalles Bibliográficos
Autores principales: Rhee, Soyoung, Kirschen, Gregory W., Gu, Yan, Ge, Shaoyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039642/
https://www.ncbi.nlm.nih.gov/pubmed/27678193
http://dx.doi.org/10.1038/srep34370