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Independent multimerization of Latent TGFβ Binding Protein-1 stabilized by cross-linking and enhanced by heparan sulfate

TGFβ plays key roles in fibrosis and cancer progression, and latency is conferred by covalent linkage to latent TGFβ binding proteins (LTBPs). LTBP1 is essential for TGFβ folding, secretion, matrix localization and activation but little is known about its structure due to its inherent size and flexi...

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Detalles Bibliográficos
Autores principales: Troilo, Helen, Steer, Ruth, Collins, Richard F., Kielty, Cay M., Baldock, Clair
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039643/
https://www.ncbi.nlm.nih.gov/pubmed/27677855
http://dx.doi.org/10.1038/srep34347