Functional characterization of p53 pathway components in the ancient metazoan Trichoplax adhaerens

The identification of genes encoding a p53 family member and an Mdm2 ortholog in the ancient placozoan Trichoplax adhaerens advocates for the evolutionary conservation of a pivotal stress-response pathway observed in all higher eukaryotes. Here, we recapitulate several key functionalities ascribed t...

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Detalles Bibliográficos
Autores principales: Siau, Jia Wei, Coffill, Cynthia R., Zhang, Weiyun Villien, Tan, Yaw Sing, Hundt, Juliane, Lane, David, Verma, Chandra, Ghadessy, Farid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039725/
https://www.ncbi.nlm.nih.gov/pubmed/27678309
http://dx.doi.org/10.1038/srep33972

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039725/
https://www.ncbi.nlm.nih.gov/pubmed/27678309
http://dx.doi.org/10.1038/srep33972

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