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General continuous-time Markov model of sequence evolution via insertions/deletions: local alignment probability computation

BACKGROUND: Insertions and deletions (indels) account for more nucleotide differences between two related DNA sequences than substitutions do, and thus it is imperative to develop a method to reliably calculate the occurrence probabilities of sequence alignments via evolutionary processes on an enti...

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Detalles Bibliográficos
Autor principal: Ezawa, Kiyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039815/
https://www.ncbi.nlm.nih.gov/pubmed/27677569
http://dx.doi.org/10.1186/s12859-016-1167-6