PARP inhibition in leukocytes diminishes inflammation via effects on integrins/cytoskeleton and protects the blood-brain barrier

BACKGROUND: Blood-brain barrier (BBB) dysfunction/disruption followed by leukocyte infiltration into the brain causes neuroinflammation and contributes to morbidity in multiple sclerosis, encephalitis, traumatic brain injury, and stroke. The identification of pathways that decreases the inflammatory...

Descripción completa

Detalles Bibliográficos
Autores principales: Rom, Slava, Zuluaga-Ramirez, Viviana, Reichenbach, Nancy L., Dykstra, Holly, Gajghate, Sachin, Pacher, Pal, Persidsky, Yuri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039899/
https://www.ncbi.nlm.nih.gov/pubmed/27677851
http://dx.doi.org/10.1186/s12974-016-0729-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039899/
https://www.ncbi.nlm.nih.gov/pubmed/27677851
http://dx.doi.org/10.1186/s12974-016-0729-x

Ejemplares similares