Cargando…

PARP inhibition in leukocytes diminishes inflammation via effects on integrins/cytoskeleton and protects the blood-brain barrier

BACKGROUND: Blood-brain barrier (BBB) dysfunction/disruption followed by leukocyte infiltration into the brain causes neuroinflammation and contributes to morbidity in multiple sclerosis, encephalitis, traumatic brain injury, and stroke. The identification of pathways that decreases the inflammatory...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rom, Slava, Zuluaga-Ramirez, Viviana, Reichenbach, Nancy L., Dykstra, Holly, Gajghate, Sachin, Pacher, Pal, Persidsky, Yuri
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039899/ https://www.ncbi.nlm.nih.gov/pubmed/27677851 http://dx.doi.org/10.1186/s12974-016-0729-x

Ejemplares similares

The dual action of poly(ADP-ribose) polymerase -1 (PARP-1) inhibition in HIV-1 infection: HIV-1 LTR inhibition and diminution in Rho GTPase activity
por: Rom, Slava, et al.
Publicado: (2015)

Combination of HIV-1 and Diabetes Enhances Blood Brain Barrier Injury via Effects on Brain Endothelium and Pericytes
por: Rom, Slava, et al.
Publicado: (2020)

Author Correction: Hyperglycemia and advanced glycation end products disrupt BBB and promote occludin and claudin-5 protein secretion on extracellular microvesicles
por: Rom, Slava, et al.
Publicado: (2020)

Hyperglycemia and advanced glycation end products disrupt BBB and promote occludin and claudin-5 protein secretion on extracellular microvesicles
por: Rom, Slava, et al.
Publicado: (2020)

Secoisolariciresinol diglucoside is a blood-brain barrier protective and anti-inflammatory agent: implications for neuroinflammation
por: Rom, Slava, et al.
Publicado: (2018)

Craniula: A cranial window technique for prolonged imaging of brain surface vasculature with simultaneous adjacent intracerebral injection
por: Zuluaga-Ramirez, Viviana, et al.
Publicado: (2015)

Inhibition of Glycogen Synthase Kinase 3β Promotes Tight Junction Stability in Brain Endothelial Cells by Half-Life Extension of Occludin and Claudin-5
por: Ramirez, Servio H., et al.
Publicado: (2013)

Tobacco smoke and morphine alter peripheral and CNS inflammation following HIV infection in a humanized mouse model
por: Cornwell, William D., et al.
Publicado: (2020)

Blocking of P2X7r Reduces Mitochondrial Stress Induced by Alcohol and Electronic Cigarette Exposure in Brain Microvascular Endothelial Cells
por: Mekala, Naveen, et al.
Publicado: (2022)

Alcohol and e-cigarette damage alveolar-epithelial barrier by activation of P2X7r and provoke brain endothelial injury via extracellular vesicles
por: Mekala, Naveen, et al.
Publicado: (2023)

Kallikrein–Kinin System Suppresses Type I Interferon Responses: A Novel Pathway of Interferon Regulation
por: Seliga, Alecia, et al.
Publicado: (2018)

Drosophila Integrin-Linked Kinase Is Required at Sites of Integrin Adhesion to Link the Cytoskeleton to the Plasma Membrane
por: Zervas, Christos G., et al.
Publicado: (2001)

From the ECM to the Cytoskeleton and Back: How Integrins Orchestrate T Cell Action
por: Epler, Jennifer A., et al.
Publicado: (2000)

Dynamic cytoskeleton-integrin associations induced by cell binding to immobilized fibronectin
Publicado: (1989)

Integrin‐associated molecules and signalling cross talking in osteoclast cytoskeleton regulation
por: Kong, Lingbo, et al.
Publicado: (2020)

Anti-Inflammatory Effect of Targeted Delivery of SOD to Endothelium: Mechanism, Synergism with NO Donors and Protective Effects In Vitro and In Vivo
por: Shuvaev, Vladimir V., et al.
Publicado: (2013)

Leukocyte adhesion to vascular endothelium induces E-selectin linkage to the actin cytoskeleton
Publicado: (1996)

Interaction of leukocyte integrins with ligand is necessary but not sufficient for function
Publicado: (1992)

Regulation of Mitotic Cytoskeleton Dynamics and Cytokinesis by Integrin-Linked Kinase in Retinoblastoma Cells
por: Sikkema, William K. A., et al.
Publicado: (2014)

Importance of Interaction between Integrin and Actin Cytoskeleton in Suspension Adaptation of CHO cells
por: Walther, Christa G., et al.
Publicado: (2015)

Cucurbitacins Elicit Anti-Platelet Activity via Perturbation of the Cytoskeleton and Integrin Function
por: Kriek, Neline, et al.
Publicado: (2022)

Muscle β1D Integrin Reinforces the Cytoskeleton–Matrix Link: Modulation of Integrin Adhesive Function by Alternative Splicing
por: Belkin, Alexey M., et al.
Publicado: (1997)

Centrally Acting Angiotensin-Converting Enzyme Inhibitor Suppresses Type I Interferon Responses and Decreases Inflammation in the Periphery and the CNS in Lupus-Prone Mice
por: Nocito, Cassandra, et al.
Publicado: (2020)

Developing machine-learning-based models to diminish the severity of injuries sustained by pedestrians in road traffic incidents
por: Elalouf, Amir, et al.
Publicado: (2023)

Gfi1b controls integrin signaling-dependent cytoskeleton dynamics and organization in megakaryocytes
por: Beauchemin, Hugues, et al.
Publicado: (2017)

Regulatory roles of fibronectin and integrin α5 in reorganization of the actin cytoskeleton and completion of adipogenesis
por: Uetaki, Megumi, et al.
Publicado: (2022)

Divalent cation regulation of the function of the leukocyte integrin LFA-1
Publicado: (1992)

Biology and structure of leukocyte β (2 )integrins and their role in inflammation
por: Arnaout, M. Amin
Publicado: (2016)

Stabilization of Endothelial Receptor Arrays by a Polarized Spectrin Cytoskeleton Facilitates Rolling and Adhesion of Leukocytes
por: Mylvaganam, Sivakami, et al.
Publicado: (2020)

Temporal Effects of Cyclic Stretching on Distribution and Gene Expression of Integrin and Cytoskeleton by Ligament Fibroblasts In Vitro
por: Kaneko, Daiki, et al.
Publicado: (2009)

The Origin and Evolution of the Plant Cell Surface: Algal Integrin-Associated Proteins and a New Family of Integrin-Like Cytoskeleton-ECM Linker Proteins
por: Becker, Burkhard, et al.
Publicado: (2015)

β2 Integrins—Multi-Functional Leukocyte Receptors in Health and Disease
por: Bednarczyk, Monika, et al.
Publicado: (2020)

Depletion of enteric bacteria diminishes leukocyte infiltration following doxorubicin-induced small intestinal damage in mice
por: Carr, Jacquelyn S., et al.
Publicado: (2017)

Let-7g* and miR-98 Reduce Stroke-Induced Production of Proinflammatory Cytokines in Mouse Brain
por: Bernstein, David L., et al.
Publicado: (2020)

Dynamic changes in the osteoclast cytoskeleton in response to growth factors and cell attachment are controlled by β3 integrin
por: Faccio, Roberta, et al.
Publicado: (2003)

Talin1 is critical for force-dependent reinforcement of initial integrin–cytoskeleton bonds but not tyrosine kinase activation
por: Giannone, Grégory, et al.
Publicado: (2003)

Infections of the nervous system
por: Gendelman, Howard E, et al.
Publicado: (2005)

Effects of the PARP Inhibitor Olaparib on the Response of Human Peripheral Blood Leukocytes to Bacterial Challenge or Oxidative Stress
por: Santos, Sidneia Sousa, et al.
Publicado: (2022)

Leukocyte response integrin and integrin-associated protein act as a signal transduction unit in generation of a phagocyte respiratory burst
Publicado: (1993)

Coordinate interactions of Csk, Src, and Syk kinases with αIIbβ3 initiate integrin signaling to the cytoskeleton
por: Obergfell, Achim, et al.
Publicado: (2002)

Cannot write session to /tmp/vufind_sessions/sess_scv80r1oe62hc7u98oj3aadsbt