Physiologically based and population PK modeling in optimizing drug development: A predict–learn–confirm analysis

Physiologically based pharmacokinetic (PBPK) modeling and classical population pharmacokinetic (PK) model‐based simulations are increasingly used to answer various drug development questions. In this study, we propose a methodology to optimize the development of drugs, primarily cleared by the kidne...

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Detalles Bibliográficos
Autores principales: Suri, A, Chapel, S, Lu, C, Venkatakrishnan, K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039936/
https://www.ncbi.nlm.nih.gov/pubmed/26031410
http://dx.doi.org/10.1002/cpt.155

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039936/
https://www.ncbi.nlm.nih.gov/pubmed/26031410
http://dx.doi.org/10.1002/cpt.155

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