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Physiologically based and population PK modeling in optimizing drug development: A predict–learn–confirm analysis
Physiologically based pharmacokinetic (PBPK) modeling and classical population pharmacokinetic (PK) model‐based simulations are increasingly used to answer various drug development questions. In this study, we propose a methodology to optimize the development of drugs, primarily cleared by the kidne...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039936/ https://www.ncbi.nlm.nih.gov/pubmed/26031410 http://dx.doi.org/10.1002/cpt.155 |