Potential for cellular stress response to hepatic factor VIII expression from AAV vector

Hemophilia A and B are coagulation disorders resulting from the loss of functional coagulation factor VIII (FVIII) or factor IX proteins, respectively. Gene therapy for hemophilia with adeno-associated virus vectors has shown efficacy in hemophilia B patients. Although hemophilia A patients are more...

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Detalles Bibliográficos
Autores principales: Zolotukhin, Irene, Markusic, David M, Palaschak, Brett, Hoffman, Brad E, Srikanthan, Meera A, Herzog, Roland W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040172/
https://www.ncbi.nlm.nih.gov/pubmed/27738644
http://dx.doi.org/10.1038/mtm.2016.63

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040172/
https://www.ncbi.nlm.nih.gov/pubmed/27738644
http://dx.doi.org/10.1038/mtm.2016.63

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