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High-Resolution Identification of Specificity Determining Positions in the LacI Protein Family Using Ensembles of Sub-Sampled Alignments

Since the advent of large-scale genomic sequencing, and the consequent availability of large numbers of homologous protein sequences, there has been burgeoning development of methods for extracting functional information from multiple sequence alignments (MSAs). One type of analysis seeks to identif...

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Detalles Bibliográficos
Autores principales: Sloutsky, Roman, Naegle, Kristen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040260/
https://www.ncbi.nlm.nih.gov/pubmed/27681038
http://dx.doi.org/10.1371/journal.pone.0162579