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Alternative Splice Variants Modulates Dominant-Negative Function of Helios in T-Cell Leukemia
The molecular defects which lead to multistep incidences of human T-cell leukemia have yet to be identified. The DNA-binding protein Helios (known as IKZF2), a member of the Ikaros family of Krüppel-like zinc-finger proteins, functions pivotally in T-cell differentiation and activation. In this stud...
Autores principales: | Zhao, Shaorong, Liu, Wei, Li, Yinghui, Liu, Pengjiang, Li, Shufang, Dou, Daolei, Wang, Yue, Yang, Rongcun, Xiang, Rong, Liu, Feifei |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040427/ https://www.ncbi.nlm.nih.gov/pubmed/27681508 http://dx.doi.org/10.1371/journal.pone.0163328 |
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