Decreases in Gap Junction Coupling Recovers Ca(2+) and Insulin Secretion in Neonatal Diabetes Mellitus, Dependent on Beta Cell Heterogeneity and Noise

Diabetes is caused by dysfunction to β-cells in the islets of Langerhans, disrupting insulin secretion and glucose homeostasis. Gap junction-mediated electrical coupling between β-cells in the islet plays a major role in coordinating a pulsatile secretory response at elevated glucose and suppressing...

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Detalles Bibliográficos
Autores principales: Notary, Aleena M., Westacott, Matthew J., Hraha, Thomas H., Pozzoli, Marina, Benninger, Richard K. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040430/
https://www.ncbi.nlm.nih.gov/pubmed/27681078
http://dx.doi.org/10.1371/journal.pcbi.1005116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040430/
https://www.ncbi.nlm.nih.gov/pubmed/27681078
http://dx.doi.org/10.1371/journal.pcbi.1005116

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