Development of a Novel Quantitative Structure-Activity Relationship Model to Accurately Predict Pulmonary Absorption and Replace Routine Use of the Isolated Perfused Respiring Rat Lung Model

PURPOSE: We developed and tested a novel Quantitative Structure-Activity Relationship (QSAR) model to better understand the physicochemical drivers of pulmonary absorption, and to facilitate compound design through improved prediction of absorption. The model was tested using a large array of both e...

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Detalles Bibliográficos
Autores principales: Edwards, Chris D., Luscombe, Chris, Eddershaw, Peter, Hessel, Edith M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040732/
https://www.ncbi.nlm.nih.gov/pubmed/27401409
http://dx.doi.org/10.1007/s11095-016-1983-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040732/
https://www.ncbi.nlm.nih.gov/pubmed/27401409
http://dx.doi.org/10.1007/s11095-016-1983-4

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