Preparation and Evaluation of a Novel Class of Amphiphilic Amines as Antitumor Agents and Nanocarriers for Bioactive Molecules

PURPOSE: We describe a novel class of antitumor amphiphilic amines (RCn) based on a tricyclic amine hydrophilic head and a hydrophobic linear alkyl tail of variable length. METHODS: We tested the lead compound, RC16, for cytotoxicity and mechanism of cell death in several cancer cell lines, anti tum...

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Detalles Bibliográficos
Autores principales: Orienti, Isabella, Falconi, Mirella, Teti, Gabriella, Currier, Mark A., Wang, Jiang, Phelps, Mitch, Cripe, Timothy P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040747/
https://www.ncbi.nlm.nih.gov/pubmed/27457066
http://dx.doi.org/10.1007/s11095-016-1999-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040747/
https://www.ncbi.nlm.nih.gov/pubmed/27457066
http://dx.doi.org/10.1007/s11095-016-1999-9

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