Antisense-Based Progerin Downregulation in HGPS-Like Patients’ Cells

Progeroid laminopathies, including Hutchinson-Gilford Progeria Syndrome (HGPS, OMIM #176670), are premature and accelerated aging diseases caused by defects in nuclear A-type Lamins. Most HGPS patients carry a de novo point mutation within exon 11 of the LMNA gene encoding A-type Lamins. This mutati...

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Detalles Bibliográficos
Autores principales: Harhouri, Karim, Navarro, Claire, Baquerre, Camille, Da Silva, Nathalie, Bartoli, Catherine, Casey, Frank, Mawuse, Guedenon Koffi, Doubaj, Yassamine, Lévy, Nicolas, De Sandre-Giovannoli, Annachiara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040973/
https://www.ncbi.nlm.nih.gov/pubmed/27409638
http://dx.doi.org/10.3390/cells5030031

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040973/
https://www.ncbi.nlm.nih.gov/pubmed/27409638
http://dx.doi.org/10.3390/cells5030031

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