Crystal structures of mono- and bi-specific diabodies and reduction of their structural flexibility by introduction of disulfide bridges at the Fv interface

Building a sophisticated protein nano-assembly requires a method for linking protein components in a predictable and stable structure. Diabodies are engineered antibody fragments that are composed of two Fv domains connected by short peptide linkers. They are attractive candidates for mediators in a...

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Detalles Bibliográficos
Autores principales: Kim, Jin Hong, Song, Dong Hyun, Youn, Suk-Jun, Kim, Ji Won, Cho, Geunyoung, Kim, Sun Chang, Lee, Hayyoung, Jin, Mi Sun, Lee, Jie-Oh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041106/
https://www.ncbi.nlm.nih.gov/pubmed/27682821
http://dx.doi.org/10.1038/srep34515

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041106/
https://www.ncbi.nlm.nih.gov/pubmed/27682821
http://dx.doi.org/10.1038/srep34515

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