A potent and selective small molecule inhibitor of sirtuin 1 promotes differentiation of pluripotent P19 cells into functional neurons

Sirtuin 1 (SIRT1) is known to suppress differentiation of pluripotent/multipotent cells and neural progenitor cells into neurons by blocking activation of transcription factors critical for neurogenesis. EX-527 is a highly selective and potent inhibitor against SIRT1 and has been used as a chemical...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Beom Seok, Lee, Chang-Hee, Chang, Gyeong-Eon, Cheong, Eunji, Shin, Injae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041152/
https://www.ncbi.nlm.nih.gov/pubmed/27680533
http://dx.doi.org/10.1038/srep34324

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041152/
https://www.ncbi.nlm.nih.gov/pubmed/27680533
http://dx.doi.org/10.1038/srep34324

Ejemplares similares