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A potent and selective small molecule inhibitor of sirtuin 1 promotes differentiation of pluripotent P19 cells into functional neurons

Sirtuin 1 (SIRT1) is known to suppress differentiation of pluripotent/multipotent cells and neural progenitor cells into neurons by blocking activation of transcription factors critical for neurogenesis. EX-527 is a highly selective and potent inhibitor against SIRT1 and has been used as a chemical...

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Detalles Bibliográficos
Autores principales:	Kim, Beom Seok, Lee, Chang-Hee, Chang, Gyeong-Eon, Cheong, Eunji, Shin, Injae
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041152/ https://www.ncbi.nlm.nih.gov/pubmed/27680533 http://dx.doi.org/10.1038/srep34324

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