Poly(ADP-ribose) polymers regulate DNA topoisomerase I (Top1) nuclear dynamics and camptothecin sensitivity in living cells

Topoisomerase 1 (Top1) is essential for removing the DNA supercoiling generated during replication and transcription. Anticancer drugs like camptothecin (CPT) and its clinical derivatives exert their cytotoxicity by reversibly trapping Top1 in covalent complexes on the DNA (Top1cc). Poly(ADP-ribose)...

Descripción completa

Detalles Bibliográficos
Autores principales: Das, Subhendu K., Rehman, Ishita, Ghosh, Arijit, Sengupta, Souvik, Majumdar, Papiya, Jana, Biman, Das, Benu Brata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041477/
https://www.ncbi.nlm.nih.gov/pubmed/27466387
http://dx.doi.org/10.1093/nar/gkw665

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041477/
https://www.ncbi.nlm.nih.gov/pubmed/27466387
http://dx.doi.org/10.1093/nar/gkw665

Ejemplares similares