Cargando…

Poly(ADP-ribose) polymers regulate DNA topoisomerase I (Top1) nuclear dynamics and camptothecin sensitivity in living cells

Topoisomerase 1 (Top1) is essential for removing the DNA supercoiling generated during replication and transcription. Anticancer drugs like camptothecin (CPT) and its clinical derivatives exert their cytotoxicity by reversibly trapping Top1 in covalent complexes on the DNA (Top1cc). Poly(ADP-ribose)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Das, Subhendu K., Rehman, Ishita, Ghosh, Arijit, Sengupta, Souvik, Majumdar, Papiya, Jana, Biman, Das, Benu Brata
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041477/ https://www.ncbi.nlm.nih.gov/pubmed/27466387 http://dx.doi.org/10.1093/nar/gkw665

Ejemplares similares

‘LeishMan’ topoisomerase I: an ideal chimera for unraveling the role of the small subunit of unusual bi-subunit topoisomerase I from Leishmania donovani
por: Ganguly, Agneyo, et al.
Publicado: (2006)

Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites
por: Altmeyer, Matthias, et al.
Publicado: (2009)

The different cleavage DNA sequence specificity explains the camptothecin resistance of the human topoisomerase I Glu418Lys mutant
por: Fiorani, Paola, et al.
Publicado: (2006)

TopA, the Sulfolobus solfataricus topoisomerase III, is a decatenase
por: Bizard, Anna H, et al.
Publicado: (2018)

Top3α is the replicative topoisomerase in mitochondrial DNA replication
por: Hangas, Anu, et al.
Publicado: (2022)

Neutral Porphyrin Derivative Exerts Anticancer Activity by Targeting Cellular Topoisomerase I (Top1) and Promotes Apoptotic Cell Death without Stabilizing Top1-DNA Cleavage Complexes
por: Das, Subhendu K., et al.
Publicado: (2017)

ATP independent type IB topoisomerase of Leishmania donovani is stimulated by ATP: an insight into the functional mechanism
por: Sengupta, Souvik, et al.
Publicado: (2011)

topIb, a phylogenetic hallmark gene of Thaumarchaeota encodes a functional eukaryote-like topoisomerase IB
por: Dahmane, Narimane, et al.
Publicado: (2016)

Bacterial topoisomerase I and topoisomerase III relax supercoiled DNA via distinct pathways
por: Terekhova, Ksenia, et al.
Publicado: (2012)

Topoisomerase 3β is the major topoisomerase for mRNAs and linked to neurodevelopment and mental dysfunction
por: Ahmad, Muzammil, et al.
Publicado: (2017)

The interaction between transport-segment DNA and topoisomerase IA—crystal structure of MtbTOP1 in complex with both G- and T-segments
por: Ferdous, Shomita, et al.
Publicado: (2022)

Roles of the C-terminal domains of topoisomerase IIα and topoisomerase IIβ in regulation of the decatenation checkpoint
por: Kozuki, Toshiyuki, et al.
Publicado: (2017)

Increased negative supercoiling of mtDNA in TOP1mt knockout mice and presence of topoisomerases IIα and IIβ in vertebrate mitochondria
por: Zhang, Hongliang, et al.
Publicado: (2014)

Comparison of DNA decatenation by Escherichia coli topoisomerase IV and topoisomerase III: implications for non-equilibrium topology simplification
por: Seol, Yeonee, et al.
Publicado: (2013)

Negative regulation of mitochondrial transcription by mitochondrial topoisomerase I
por: Sobek, Stefan, et al.
Publicado: (2013)

The role of DNA bending in type IIA topoisomerase function
por: Lee, Imsang, et al.
Publicado: (2013)

Immunodetection of human topoisomerase I-DNA covalent complexes
por: Patel, Anand G., et al.
Publicado: (2016)

Activities of gyrase and topoisomerase IV on positively supercoiled DNA
por: Ashley, Rachel E., et al.
Publicado: (2017)

Dynamic and facilitated binding of topoisomerase accelerates topological relaxation
por: Michieletto, Davide, et al.
Publicado: (2022)

PARP1–TDP1 coupling for the repair of topoisomerase I–induced DNA damage
por: Das, Benu Brata, et al.
Publicado: (2014)

RecA can stimulate the relaxation activity of topoisomerase I: Molecular basis of topoisomerase-mediated genome-wide transcriptional responses in Escherichia coli
por: Reckinger, Amy R., et al.
Publicado: (2007)

PRMT5-mediated arginine methylation of TDP1 for the repair of topoisomerase I covalent complexes
por: Rehman, Ishita, et al.
Publicado: (2018)

Centromere-associated topoisomerase activity in bloodstream form Trypanosoma brucei
por: Obado, Samson O., et al.
Publicado: (2011)

Direct regulation of topoisomerase activity by a nucleoid-associated protein
por: Ghosh, Soumitra, et al.
Publicado: (2014)

Binding of two DNA molecules by type II topoisomerases for decatenation
por: Kumar, Rupesh, et al.
Publicado: (2012)

Regulation of the catalytic function of topoisomerase II alpha through association with RNA
por: Park, Seung-Won, et al.
Publicado: (2008)

Use of divalent metal ions in the DNA cleavage reaction of topoisomerase IV
por: Pitts, Steven L., et al.
Publicado: (2011)

A highly processive topoisomerase I: studies at the single-molecule level
por: Szafran, Marcin Jan, et al.
Publicado: (2014)

RNA topoisomerase is prevalent in all domains of life and associates with polyribosomes in animals
por: Ahmad, Muzammil, et al.
Publicado: (2016)

Transcriptional supercoiling boosts topoisomerase II-mediated knotting of intracellular DNA
por: Valdés, Antonio, et al.
Publicado: (2019)

Two type I topoisomerases maintain DNA topology in human mitochondria
por: Menger, Katja E, et al.
Publicado: (2022)

Structural basis for topoisomerase VI inhibition by the anti-Hsp90 drug radicicol
por: Corbett, Kevin D., et al.
Publicado: (2006)

The geometry of DNA supercoils modulates the DNA cleavage activity of human topoisomerase I
por: Gentry, Amanda C., et al.
Publicado: (2011)

Functional determinants of gate-DNA selection and cleavage by bacterial type II topoisomerases
por: Arnoldi, Elisa, et al.
Publicado: (2013)

Deacetylation of topoisomerase I is an important physiological function of E. coli CobB
por: Zhou, Qingxuan, et al.
Publicado: (2017)

Ciprofloxacin impairs mitochondrial DNA replication initiation through inhibition of Topoisomerase 2
por: Hangas, Anu, et al.
Publicado: (2018)

HMGB1 interacts with human topoisomerase IIα and stimulates its catalytic activity
por: Štros, Michal, et al.
Publicado: (2007)

Reversal of DNA damage induced Topoisomerase 2 DNA–protein crosslinks by Tdp2
por: Schellenberg, Matthew J., et al.
Publicado: (2016)

The reverse gyrase helicase-like domain is a nucleotide-dependent switch that is attenuated by the topoisomerase domain
por: del Toro Duany, Yoandris, et al.
Publicado: (2008)

Human topoisomerase IIα uses a two-metal-ion mechanism for DNA cleavage
por: Deweese, Joseph E., et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_u8ob8gr206s4ak3meojh10tdem