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The matricellular protein CCN6 (WISP3) decreases Notch1 and suppresses breast cancer initiating cells

Increasing evidence supports that the epithelial to mesenchymal transition (EMT) in breast cancer cells generates tumor initiating cells (TICs) but the contribution of the tumor microenvironment to these programs needs further elucidation. CCN6 (WISP3) is a secreted matrix-associated protein (36.9 k...

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Detalles Bibliográficos
Autores principales: Huang, Wei, Martin, Emily E., Burman, Boris, Gonzalez, Maria E., Kleer, Celina G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041896/
https://www.ncbi.nlm.nih.gov/pubmed/26933820
http://dx.doi.org/10.18632/oncotarget.7734