Cargando…

The matricellular protein CCN6 (WISP3) decreases Notch1 and suppresses breast cancer initiating cells

Increasing evidence supports that the epithelial to mesenchymal transition (EMT) in breast cancer cells generates tumor initiating cells (TICs) but the contribution of the tumor microenvironment to these programs needs further elucidation. CCN6 (WISP3) is a secreted matrix-associated protein (36.9 k...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Wei, Martin, Emily E., Burman, Boris, Gonzalez, Maria E., Kleer, Celina G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041896/ https://www.ncbi.nlm.nih.gov/pubmed/26933820 http://dx.doi.org/10.18632/oncotarget.7734

Ejemplares similares

On how CCN6 suppresses breast cancer growth and invasion
por: Huang, Wei, et al.
Publicado: (2011)

Matricellular CCN proteins
por: Perbal, Bernard
Publicado: (2008)

Inhibition of CCN6 (WISP3) expression promotes neoplastic progression and enhances the effects of insulin-like growth factor-1 on breast epithelial cells
por: Zhang, Yanhong, et al.
Publicado: (2005)

MMTV-cre;Ccn6 knockout mice develop tumors recapitulating human metaplastic breast carcinomas
por: Martin, Emily E., et al.
Publicado: (2016)

The matricellular protein CCN3 regulates NOTCH1 signalling in chronic myeloid leukaemia
por: Suresh, Sukanya, et al.
Publicado: (2013)

The Matricellular Protein CCN1 Suppresses Hepatocarcinogenesis by Inhibiting Compensatory Proliferation
por: Chen, Chih-Chiun, et al.
Publicado: (2015)

CCN5/WISP2 and metabolic diseases
por: Grünberg, John R, et al.
Publicado: (2017)

The role of CCN4/WISP-1 in the cancerous phenotype
por: Nivison, Mary P, et al.
Publicado: (2018)

CYR61/CCN1 and WISP3/CCN6 are chemoattractive ligands for human multipotent mesenchymal stroma cells
por: Schütze, Norbert, et al.
Publicado: (2007)

Matricellular protein CCN1 mediates doxorubicin-induced cardiomyopathy in mice
por: Hsu, Pei-Ling, et al.
Publicado: (2016)

Roles of matricellular CCN2 deposited by osteocytes in osteoclastogenesis and osteoblast differentiation
por: Nishida, Takashi, et al.
Publicado: (2019)

Prospects and Perspectives for WISP1 (CCN4) in Diabetes Mellitus
por: Maiese, Kenneth
Publicado: (2020)

The Matricellular Protein CCN1 Promotes Mucosal Healing in Murine Colitis through IL-6
por: Choi, Jacob S., et al.
Publicado: (2015)

Role of Matricellular CCN Proteins in Skeletal Muscle: Focus on CCN2/CTGF and Its Regulation by Vasoactive Peptides
por: Rebolledo, Daniela L., et al.
Publicado: (2021)

WISP2/CCN5 Suppresses Vasculogenic Mimicry through Inhibition of YAP/TAZ Signaling in Breast Cancer Cells
por: Ferrand, Nathalie, et al.
Publicado: (2022)

New Insights into the Function of the Matricellular CCN1: an Emerging Target in Proliferative Retinopathies
por: Chaqour, Brahim
Publicado: (2013)

The Matricellular Protein CCN1 Mediates Neutrophil Efferocytosis in Cutaneous Wound Healing
por: Jun, Joon-Il, et al.
Publicado: (2015)

Matricellular proteins of the Cyr61/CTGF/NOV (CCN) family and the nervous system
por: Malik, Anna R., et al.
Publicado: (2015)

The matricellular protein CCN5 inhibits fibrotic deformation of retinal pigment epithelium
por: Yoon, Aeri, et al.
Publicado: (2018)

The matricellular protein CCN5 prevents adverse atrial structural and electrical remodelling
por: Lee, Min‐Ah, et al.
Publicado: (2020)

WISP3 and RhoC guanosine triphosphatase cooperate in the development of inflammatory breast cancer
por: Kleer, Celina G, et al.
Publicado: (2004)

Normal growth and development in mice over-expressing the CCN family member WISP3
por: Nakamura, Yukio, et al.
Publicado: (2009)

WISP-1/CCN4 Regulates Osteogenesis by Enhancing BMP-2 Activity
por: Ono, Mitsuaki, et al.
Publicado: (2011)

An Update to the WISP-1/CCN4 Role in Obesity, Insulin Resistance and Diabetes
por: Mirr, Małgorzata, et al.
Publicado: (2021)

CCN4/WISP1 Promotes Migration of Human Primary Osteoarthritic Chondrocytes
por: Timmermans, Ritchie G.M., et al.
Publicado: (2022)

The carboxyl-terminal TSP1-homology domain is the biologically active effector peptide of matricellular protein CCN5 that counteracts profibrotic CCN2
por: Zolfaghari, Sima, et al.
Publicado: (2022)

Metabolic Effects of CCN5/WISP2 Gene Deficiency and Transgenic Overexpression in Mice
por: Alami, Tara, et al.
Publicado: (2021)

Deadly liaisons: fatal attraction between CCN matricellular proteins and the tumor necrosis factor family of cytokines
por: Chen, Chih-Chiun, et al.
Publicado: (2009)

WISP1/CCN4 inhibits adipocyte differentiation through repression of PPARγ activity
por: Ferrand, Nathalie, et al.
Publicado: (2017)

CCN5/WISP-2 restores ER-∝ in normal and neoplastic breast cells and sensitizes triple negative breast cancer cells to tamoxifen
por: Sarkar, S, et al.
Publicado: (2017)

The Matricellular Protein CCN1/CYR61 Induces Fibroblast Senescence and Restricts Fibrosis in Cutaneous Wound Healing
por: Jun, Joon-Il, et al.
Publicado: (2010)

The TSP-1 domain of the matricellular protein CCN5 is essential for its nuclear localization and anti-fibrotic function
por: Song, Min Ho, et al.
Publicado: (2022)

WISP1/CCN4: A Potential Target for Inhibiting Prostate Cancer Growth and Spread to Bone
por: Ono, Mitsuaki, et al.
Publicado: (2013)

Picking a bone with WISP1 (CCN4): new strategies against degenerative joint disease
por: Maiese, Kenneth
Publicado: (2016)

Association of WISP1/CCN4 with Risk of Overweight and Gestational Diabetes Mellitus in Chinese Pregnant Women
por: Liu, Lei, et al.
Publicado: (2020)

The matricellular protein CCN5 induces apoptosis in myofibroblasts through SMAD7-mediated inhibition of NFκB
por: Nguyen, Mai Tuyet, et al.
Publicado: (2022)

Revisiting the matricellular concept
por: Murphy-Ullrich, Joanne E., et al.
Publicado: (2014)

Deficiency of CCN5/WISP-2-Driven Program in breast cancer Promotes Cancer Epithelial cells to mesenchymal stem cells and Breast Cancer growth
por: Das, Amlan, et al.
Publicado: (2017)

Loss of WISP2/CCN5 in Estrogen-Dependent MCF7 Human Breast Cancer Cells Promotes a Stem-Like Cell Phenotype
por: Ferrand, Nathalie, et al.
Publicado: (2014)

SAT045 Sexually Dimorphic Effects Of CCN5/WISP2 Overexpression On HFD-STZ Induced Diabetes And Glucose Intolerance
por: Alami, Tara, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_a1du4c2psgn6iaeukae3i8gcnc