mTOR complex-2 stimulates acetyl-CoA and de novo lipogenesis through ATP citrate lyase in HER2/PIK3CA-hyperactive breast cancer

The mechanistic target of rapamycin (mTOR) is a major regulator of cell growth and is frequently dysregulated in cancer. While mTOR complex-1 (mTORC1) is a validated cancer target, the role of mTOR complex-2 (mTORC2) remains less defined. Here, we reveal mTORC2 as a critical regulator of breast canc...

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Detalles Bibliográficos
Autores principales: Chen, Yaqing, Qian, Jianchang, He, Qun, Zhao, Hui, Toral-Barza, Lourdes, Shi, Celine, Zhang, Xuesai, Wu, Jiang, Yu, Ker
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041899/
https://www.ncbi.nlm.nih.gov/pubmed/27015560
http://dx.doi.org/10.18632/oncotarget.8279

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041899/
https://www.ncbi.nlm.nih.gov/pubmed/27015560
http://dx.doi.org/10.18632/oncotarget.8279

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