Cargando…

Chronic TGFβ stimulation promotes the metastatic potential of lung cancer cells by Snail protein stabilization through integrin β3-Akt-GSK3β signaling

Chronic exposure to TGFβ, a frequent occurrence for tumor cells in the tumor microenvironment, confers more aggressive phenotypes on cancer cells by promoting their invasion and migration while at the same time increasing their resistance to the growth-inhibitory effect of TGFβ. In this study, a tra...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bae, Gab-Yong, Hong, Soon-Ki, Park, Jeong-Rak, Kwon, Ok-Seon, Kim, Keun-Tae, Koo, JaeHyung, Oh, Ensel, Cha, Hyuk-Jin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041910/ https://www.ncbi.nlm.nih.gov/pubmed/27015122 http://dx.doi.org/10.18632/oncotarget.8295

Ejemplares similares

ASIC1a stimulates the resistance of human hepatocellular carcinoma by promoting EMT via the AKT/GSK3β/Snail pathway driven by TGFβ/Smad signals
por: Zhang, Yinci, et al.
Publicado: (2022)

AKT/GSK3β Signaling in Glioblastoma
por: Majewska, Ewelina, et al.
Publicado: (2016)

Multi-walled carbon nanotubes directly induce epithelial-mesenchymal transition in human bronchial epithelial cells via the TGF-β-mediated Akt/GSK-3β/SNAIL-1 signalling pathway
por: Polimeni, Manuela, et al.
Publicado: (2016)

STK17B promotes carcinogenesis and metastasis via AKT/GSK-3β/Snail signaling in hepatocellular carcinoma
por: Lan, Yaliang, et al.
Publicado: (2018)

Biejiajian Pill Inhibits Carcinogenesis and Metastasis via the Akt/GSK-3β/Snail Signaling Pathway in Hepatocellular Carcinoma
por: Sun, Jialing, et al.
Publicado: (2021)

CHN1 promotes epithelial–mesenchymal transition via the Akt/GSK-3β/Snail pathway in cervical carcinoma
por: Zhao, Haoqi, et al.
Publicado: (2021)

The TGF‐β‐induced up‐regulation of NKG2DLs requires AKT/GSK‐3β‐mediated stabilization of SP1
por: Chen, Xiao‐Hui, et al.
Publicado: (2017)

SCUBE3 downregulation modulates hepatocellular carcinoma by inhibiting CCNE1 via TGFβ/PI3K/AKT/GSK3β pathway
por: Xu, Pan, et al.
Publicado: (2022)

Targeted inactivation of β1 integrin induces β3 integrin switching, which drives breast cancer metastasis by TGF-β
por: Parvani, Jenny G., et al.
Publicado: (2013)

Mannose Suppresses the Proliferation and Metastasis of Lung Cancer by Targeting the ERK/GSK-3β/β-Catenin/SNAIL Axis
por: Luo, Qingsong, et al.
Publicado: (2020)

DEPDC1B promotes migration and invasion in pancreatic ductal adenocarcinoma by activating the Akt/GSK3β/Snail pathway
por: Liu, Xu, et al.
Publicado: (2020)

Overexpression of FBXO17 Promotes the Proliferation, Migration and Invasion of Glioma Cells Through the Akt/GSK-3β/Snail Pathway
por: Wang, Ning, et al.
Publicado: (2021)

PRMT9 promotes hepatocellular carcinoma invasion and metastasis via activating PI3K/Akt/GSK‐3β/Snail signaling
por: Jiang, Hai, et al.
Publicado: (2018)

Correction for Targeted inactivation of β1 integrin induces β3 integrin switching, which drives breast cancer metastasis by TGF-β
Publicado: (2014)

TGFβ-mediated expression of TGFβ-activating integrins in SSc monocytes: disturbed activation of latent TGFβ?
por: van Caam, A., et al.
Publicado: (2020)

αvβ3 Integrin induces partial EMT independent of TGF-β signaling
por: Kariya, Yoshinobu, et al.
Publicado: (2021)

Epithelial–Mesenchymal Transition (EMT) Induced by TNF-α Requires AKT/GSK-3β-Mediated Stabilization of Snail in Colorectal Cancer
por: Wang, Hao, et al.
Publicado: (2013)

Different expression of GSK3β and pS9GSK3β depending on phenotype of cervical cancer: possible association of GSK3β with squamous cell carcinoma and pS9GSK3β with adenocarcinoma
por: Ahn, Kwanghee, et al.
Publicado: (2019)

Tumor-derived CXCL5 promotes human colorectal cancer metastasis through activation of the ERK/Elk-1/Snail and AKT/GSK3β/β-catenin pathways
por: Zhao, Jingkun, et al.
Publicado: (2017)

Imperatorin promotes osteogenesis and suppresses osteoclast by activating AKT/GSK3 β/β‐catenin pathways
por: Yan, De‐Yi, et al.
Publicado: (2019)

Girdin acts as an oncogene in gastric cancer by regulating AKT/GSK3β/β-catenin signaling
por: Wang, Yun, et al.
Publicado: (2023)

A Water-Soluble Hydrogen Sulfide Donor Suppresses the Growth of Hepatocellular Carcinoma via Inhibiting the AKT/GSK-3β/β-Catenin and TGF-β/Smad2/3 Signaling Pathways
por: Duan, Shao-Feng, et al.
Publicado: (2023)

Mesenchymal stem cells ameliorate renal fibrosis by galectin-3/Akt/GSK3β/Snail signaling pathway in adenine-induced nephropathy rat
por: Tang, Huajun, et al.
Publicado: (2021)

Zidovudine, an anti-viral drug, resensitizes gemcitabine-resistant pancreatic cancer cells to gemcitabine by inhibition of the Akt-GSK3β-Snail pathway
por: Namba, T, et al.
Publicado: (2015)

The potential dual effects of sevoflurane on AKT/GSK3β signaling pathway
por: Zhang, Lei, et al.
Publicado: (2014)

Acute Ethanol Inhibition of γ Oscillations Is Mediated by Akt and GSK3β
por: Wang, JianGang, et al.
Publicado: (2016)

Age-related neuroinflammation and changes in AKT-GSK-3β and WNT/ β-CATENIN signaling in rat hippocampus
por: Orellana, Ana Maria Marques, et al.
Publicado: (2015)

Amine derivatives of furocoumarin induce melanogenesis by activating Akt/GSK-3β/β-catenin signal pathway
por: Zang, Deng, et al.
Publicado: (2019)

Milk Exosome-Derived MicroRNA-2478 Suppresses Melanogenesis through the Akt-GSK3β Pathway
por: Bae, In-Seon, et al.
Publicado: (2021)

GSK-3β and memory formation
por: Takashima, Akihiko
Publicado: (2012)

GSK3β and aging liver
por: Jin, Jingling, et al.
Publicado: (2009)

GSK3β and the aging kidney
por: Kreidberg, Jordan A., et al.
Publicado: (2022)

Novel Reporter Alleles of GSK-3α and GSK-3β
por: Barrell, William B., et al.
Publicado: (2012)

Dieckol Ameliorates Aβ Production via PI3K/Akt/GSK-3β Regulated APP Processing in SweAPP N2a Cell
por: Yoon, Jeong-Hyun, et al.
Publicado: (2021)

Integrin Beta 3 Regulates Cellular Senescence by Activating the TGF-β Pathway
por: Rapisarda, Valentina, et al.
Publicado: (2017)

TGFβ(1 )signaling via α(V)β(6 )integrin
por: Kracklauer, Martin P, et al.
Publicado: (2003)

No substitute for β3 integrin
por: Leslie, Mitch
Publicado: (2015)

CCL21 Facilitates Chemoresistance and Cancer Stem Cell-Like Properties of Colorectal Cancer Cells through AKT/GSK-3β/Snail Signals
por: Lu, Lin-Lin, et al.
Publicado: (2016)

Resveratrol inhibits the invasion and metastasis of colon cancer through reversal of epithelial- mesenchymal transition via the AKT/GSK-3β/Snail signaling pathway
por: Yuan, Li, et al.
Publicado: (2019)

Resveratrol inhibits the invasion and metastasis of colon cancer through reversal of epithelial-mesenchymal transition via the AKT/GSK-3β/Snail signaling pathway
por: Yuan, Li, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_42489tugqn8o7ri1svpe2luc0j