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Chronic TGFβ stimulation promotes the metastatic potential of lung cancer cells by Snail protein stabilization through integrin β3-Akt-GSK3β signaling
Chronic exposure to TGFβ, a frequent occurrence for tumor cells in the tumor microenvironment, confers more aggressive phenotypes on cancer cells by promoting their invasion and migration while at the same time increasing their resistance to the growth-inhibitory effect of TGFβ. In this study, a tra...
Autores principales: | Bae, Gab-Yong, Hong, Soon-Ki, Park, Jeong-Rak, Kwon, Ok-Seon, Kim, Keun-Tae, Koo, JaeHyung, Oh, Ensel, Cha, Hyuk-Jin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041910/ https://www.ncbi.nlm.nih.gov/pubmed/27015122 http://dx.doi.org/10.18632/oncotarget.8295 |
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