Oxidative stress at low levels can induce clustered DNA lesions leading to NHEJ mediated mutations

DNA damage and mutations induced by oxidative stress are associated with various different human pathologies including cancer. The facts that most human tumors are characterized by large genome rearrangements and glutathione depletion in mice results in deletions in DNA suggest that reactive oxygen...

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Detalles Bibliográficos
Autores principales: Sharma, Vyom, Collins, Leonard B., Chen, Ting-huei, Herr, Natalie, Takeda, Shunichi, Sun, Wei, Swenberg, James A., Nakamura, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041911/
https://www.ncbi.nlm.nih.gov/pubmed/27015367
http://dx.doi.org/10.18632/oncotarget.8298

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041911/
https://www.ncbi.nlm.nih.gov/pubmed/27015367
http://dx.doi.org/10.18632/oncotarget.8298

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