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Oxidative stress at low levels can induce clustered DNA lesions leading to NHEJ mediated mutations
DNA damage and mutations induced by oxidative stress are associated with various different human pathologies including cancer. The facts that most human tumors are characterized by large genome rearrangements and glutathione depletion in mice results in deletions in DNA suggest that reactive oxygen...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals LLC
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041911/ https://www.ncbi.nlm.nih.gov/pubmed/27015367 http://dx.doi.org/10.18632/oncotarget.8298 |