Trichlorobenzene-substituted azaaryl compounds as novel FGFR inhibitors exhibiting potent antitumor activity in bladder cancer cells in vitro and in vivo

In the present study, we examined the antitumor activity of a series of trichlorobenzene-substituted azaaryl compounds and identified MPT0L145 as a novel FGFR inhibitor with better selectivity for FGFR1, 2 and 3. It was preferentially effective in FGFR-activated cancer cells, including bladder cance...

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Detalles Bibliográficos
Autores principales: Chen, Chun-Han, Liu, Yi-Min, Pan, Shiow-Lin, Liu, Yun-Ru, Liou, Jing-Ping, Yen, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041986/
https://www.ncbi.nlm.nih.gov/pubmed/27029060
http://dx.doi.org/10.18632/oncotarget.8380

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041986/
https://www.ncbi.nlm.nih.gov/pubmed/27029060
http://dx.doi.org/10.18632/oncotarget.8380

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