Inhibition of mitochondrial 2-oxoglutarate dehydrogenase impairs viability of cancer cells in a cell-specific metabolism-dependent manner

2-Oxoglutarate dehydrogenase (OGDH) of the tricarboxylic acid (TCA) cycle is often implied to be inactive in cancer, but this was not experimentally tested. We addressed the question through specific inhibition of OGDH by succinyl phosphonate (SP). SP action on different cancer cells was investigate...

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Detalles Bibliográficos
Autores principales: Bunik, Victoria I., Mkrtchyan, Garik, Grabarska, Aneta, Oppermann, Henry, Daloso, Danilo, Araujo, Wagner L., Juszczak, Malgorzata, Rzeski, Wojciech, Bettendorff, Lucien, Fernie, Alisdair R., Meixensberger, Jürgen, Stepulak, Andrzej, Gaunitz, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041988/
https://www.ncbi.nlm.nih.gov/pubmed/27027236
http://dx.doi.org/10.18632/oncotarget.8387

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041988/
https://www.ncbi.nlm.nih.gov/pubmed/27027236
http://dx.doi.org/10.18632/oncotarget.8387

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