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Receptor occupancy assessment by flow cytometry as a pharmacodynamic biomarker in biopharmaceutical development
Receptor occupancy (RO) assays are designed to quantify the binding of therapeutics to their targets on the cell surface and are frequently used to generate pharmacodynamic (PD) biomarker data in nonclinical and clinical studies of biopharmaceuticals. When combined with the pharmacokinetic (PK) prof...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042057/ https://www.ncbi.nlm.nih.gov/pubmed/26054054 http://dx.doi.org/10.1002/cyto.b.21259 |