Receptor occupancy assessment by flow cytometry as a pharmacodynamic biomarker in biopharmaceutical development

Receptor occupancy (RO) assays are designed to quantify the binding of therapeutics to their targets on the cell surface and are frequently used to generate pharmacodynamic (PD) biomarker data in nonclinical and clinical studies of biopharmaceuticals. When combined with the pharmacokinetic (PK) prof...

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Detalles Bibliográficos
Autores principales: Liang, Meina, Schwickart, Martin, Schneider, Amy K., Vainshtein, Inna, Del Nagro, Christopher, Standifer, Nathan, Roskos, Lorin K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042057/
https://www.ncbi.nlm.nih.gov/pubmed/26054054
http://dx.doi.org/10.1002/cyto.b.21259

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