Cargando…

Structural characterization of single nucleotide variants at ligand binding sites and enzyme active sites of human proteins

Functional sites on proteins play an important role in various molecular interactions and reactions between proteins and other molecules. Thus, mutations in functional sites can severely affect the overall phenotype. Progress of genome sequencing projects has yielded a wealth of information on singl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yamada, Kazunori D., Nishi, Hafumi, Nakata, Junichi, Kinoshita, Kengo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Biophysical Society of Japan (BSJ) 2016
Materias:	Regular Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042176/ https://www.ncbi.nlm.nih.gov/pubmed/27924270 http://dx.doi.org/10.2142/biophysico.13.0_157

Ejemplares similares

Distribution of single‐nucleotide variants on protein–protein interaction sites and its relationship with minor allele frequency
por: Nishi, Hafumi, et al.
Publicado: (2015)

Single-cell RNA-seq public data reveal the gene regulatory network landscape of respiratory epithelial and peripheral immune cells in COVID-19 patients
por: Zhang, Lin, et al.
Publicado: (2023)

Ligand-binding site prediction of proteins based on known fragment–fragment interactions
por: Kasahara, Kota, et al.
Publicado: (2010)

Dynamic profile analysis to characterize dynamics-driven allosteric sites in enzymes
por: Taguchi, Junko, et al.
Publicado: (2016)

PiSite: a database of protein interaction sites using multiple binding states in the PDB
por: Higurashi, Miho, et al.
Publicado: (2009)

Identification of the sequence determinants of protein N-terminal acetylation through a decision tree approach
por: Yamada, Kazunori D., et al.
Publicado: (2017)

Are sites with multiple single nucleotide variants in cancer genomes a consequence of drivers, hypermutable sites or sequencing errors?
por: Smith, Thomas C.A., et al.
Publicado: (2016)

Visualization of Chemokine Binding Sites on Human Brain Microvessels
por: Andjelkovic, Anuska V., et al.
Publicado: (1999)

Genome-wide identification and tissue-specific expression analysis of nucleotide binding site-leucine rich repeat gene family in Cicer arietinum (kabuli chickpea)
por: Sharma, Ranu, et al.
Publicado: (2017)

Single Nucleotide Polymorphisms in MicroRNA Binding Sites: Implications in Colorectal Cancer
por: Bhaumik, Panchalee, et al.
Publicado: (2014)

Severe MgADP Inhibition of Bacillus subtilis F(1)-ATPase Is Not Due to the Absence of Nucleotide Binding to the Noncatalytic Nucleotide Binding Sites
por: Ishikawa, Toru, et al.
Publicado: (2014)

Myelin 2′,3′-Cyclic Nucleotide 3′-Phosphodiesterase: Active-Site Ligand Binding and Molecular Conformation
por: Myllykoski, Matti, et al.
Publicado: (2012)

GalaxySite: ligand-binding-site prediction by using molecular docking
por: Heo, Lim, et al.
Publicado: (2014)

GraphSite: Ligand Binding Site Classification with Deep Graph Learning
por: Shi, Wentao, et al.
Publicado: (2022)

A Single Nucleotide Polymorphism Translates into a Radical Amino Acid Substitution at the Ligand-Binding Site in Fasciola hepatica Carboxylesterase B
por: Miranda-Miranda, Estefan, et al.
Publicado: (2022)

Identification of Nucleocapsid Binding Sites within Coronavirus-Defective Genomes()
por: Cologna, Raymond, et al.
Publicado: (2000)

The nucleotide-binding site of Aquifex aeolicus LpxC
por: Buetow, Lori, et al.
Publicado: (2006)

Sequence variation in ligand binding sites in proteins
por: Magliery, Thomas J, et al.
Publicado: (2005)

An alternate binding site for PPARγ ligands
por: Hughes, Travis S., et al.
Publicado: (2014)

Comparative analysis of LIN28-RNA binding sites identified at single nucleotide resolution
por: Ransey, Elizabeth, et al.
Publicado: (2017)

Discrepancies between human DNA, mRNA and protein reference sequences and their relation to single nucleotide variants in the human population
por: Shirota, Matsuyuki, et al.
Publicado: (2016)

Characterization of the High-Affinity Drug Ligand Binding Site of Mouse Recombinant TSPO
por: Iatmanen-Harbi, Soria, et al.
Publicado: (2019)

Single Nucleotide Polymorphisms at a Distance from Aryl Hydrocarbon Receptor (AHR) Binding Sites Influence AHR Ligand–Dependent Gene Expression
por: Neavin, Drew R., et al.
Publicado: (2019)

3DLigandSite: predicting ligand-binding sites using similar structures
por: Wass, Mark N., et al.
Publicado: (2010)

3DLigandSite: structure-based prediction of protein–ligand binding sites
por: McGreig, Jake E, et al.
Publicado: (2022)

Landscape of protein–small ligand binding modes
por: Kasahara, Kota, et al.
Publicado: (2016)

LISE: a server using ligand-interacting and site-enriched protein triangles for prediction of ligand-binding sites
por: Xie, Zhong-Ru, et al.
Publicado: (2013)

Ligand-binding specificity and promiscuity of the main lignocellulolytic enzyme families as revealed by active-site architecture analysis
por: Tian, Li, et al.
Publicado: (2016)

Conformational changes in the catalytically inactive nucleotide-binding site of CFTR
por: Csanády, László, et al.
Publicado: (2013)

The Nucleotide-Binding Sites of SUR1: A Mechanistic Model
por: Vedovato, Natascia, et al.
Publicado: (2015)

Nucleotide Interdependency in Transcription Factor Binding Sites in the Drosophila Genome
por: Dresch, Jacqueline M., et al.
Publicado: (2016)

SitesBase: a database for structure-based protein–ligand binding site comparisons
por: Gold, Nicola D., et al.
Publicado: (2006)

Identification of functional single nucleotide polymorphisms in the branchpoint site
por: Chiang, Hung-Lun, et al.
Publicado: (2017)

Sequencing abasic sites in DNA at single-nucleotide resolution
por: Liu, Zheng J., et al.
Publicado: (2019)

Putative ligand binding sites of two functionally characterized bark beetle odorant receptors
por: Yuvaraj, Jothi K., et al.
Publicado: (2021)

Evolutionary trace analysis at the ligand binding site of laccase
por: Mohamad, Saharuddin Bin, et al.
Publicado: (2008)

Bifunctional Avidin with Covalently Modifiable Ligand Binding Site
por: Leppiniemi, Jenni, et al.
Publicado: (2011)

Cloud Computing for Protein-Ligand Binding Site Comparison
por: Hung, Che-Lun, et al.
Publicado: (2013)

Paramagnetic Ligand Tagging To Identify Protein Binding Sites
por: Brath, Ulrika, et al.
Publicado: (2015)

Neofunctionalization in Ligand Binding Sites of Ant Olfactory Receptors
por: Saad, Rana, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_209ebmg055pgv9had8nvln634v