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TopBP1 contributes to the chemoresistance in non-small cell lung cancer through upregulation of p53

Resistance to chemotherapeutic drugs is a major obstacle in non-small cell lung cancer (NSCLC) therapy. The molecular determinants of NSCLC resistance to doxorubicin are unknown. In the present study, we investigated whether topoisomerase IIβ binding protein 1 (TopBP1) was involved in the chemoresis...

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Detalles Bibliográficos
Autores principales:	Lv, Yinxiang, Huo, Yanan, Yu, Xican, Liu, Rongrong, Zhang, Shufen, Zheng, Xiaoxiao, Zhang, Xianning
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2016
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042189/ https://www.ncbi.nlm.nih.gov/pubmed/27729767 http://dx.doi.org/10.2147/DDDT.S90705

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