Parkinson-associated risk variant in enhancer element produces subtle effect on target gene expression

Genome-wide association studies (GWAS) have identified numerous genetic variants associated with complex diseases but mechanistic insights are impeded by the lack of understanding of how specific risk variants functionally contribute to the underlying pathogenesis(1). It has been proposed that cis-a...

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Detalles Bibliográficos
Autores principales: Soldner, Frank, Stelzer, Yonatan, Shivalila, Chikdu S., Abraham, Brian J., Latourelle, Jeanne C., Barrasa, M. Inmaculada, Goldmann, Johanna, Myers, Richard H., Young, Richard A., Jaenisch, Rudolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042324/
https://www.ncbi.nlm.nih.gov/pubmed/27096366
http://dx.doi.org/10.1038/nature17939

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042324/
https://www.ncbi.nlm.nih.gov/pubmed/27096366
http://dx.doi.org/10.1038/nature17939

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