ZnT2-Mediated Zinc Import Into Paneth Cell Granules Is Necessary for Coordinated Secretion and Paneth Cell Function in Mice

BACKGROUND & AIMS: Defects in Paneth cell (PC) function are associated with microbial dysbiosis and intestinal inflammation. PC granules contain antimicrobial peptides, cytokines, and substantial stores of zinc (Zn). We hypothesized that Zn, transported into the granule through the Zn transporte...

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Detalles Bibliográficos
Autores principales: Podany, Abigail B., Wright, Justin, Lamendella, Regina, Soybel, David I., Kelleher, Shannon L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042355/
https://www.ncbi.nlm.nih.gov/pubmed/28174721
http://dx.doi.org/10.1016/j.jcmgh.2015.12.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042355/
https://www.ncbi.nlm.nih.gov/pubmed/28174721
http://dx.doi.org/10.1016/j.jcmgh.2015.12.006

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