Generation of VDR Knock-Out Mice via Zygote Injection of CRISPR/Cas9 System

CRISPR/Cas9 system has become a new versatile technology for genome engineering in various species. To achieve targeted modifications at the same site in both human and mice genomes by a CRISPR/Cas9 nuclease, we designed two target sites in conserved regions of vitamin D receptor (VDR) gene, which c...

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Detalles Bibliográficos
Autores principales: Zhang, Tao, Yin, Yajun, Liu, Huan, Du, Weili, Ren, Chonghua, Wang, Ling, Lu, Hongzhao, Zhang, Zhiying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042489/
https://www.ncbi.nlm.nih.gov/pubmed/27685656
http://dx.doi.org/10.1371/journal.pone.0163551

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042489/
https://www.ncbi.nlm.nih.gov/pubmed/27685656
http://dx.doi.org/10.1371/journal.pone.0163551

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