Single Synonymous Mutations in KRAS Cause Transformed Phenotypes in NIH(3)T(3) Cells

Synonymous mutations in the KRAS gene are clustered at G12, G13, and G60 in human cancers. We constructed 9 stable NIH(3)T(3) cell lines expressing KRAS, each with one of these synonymous mutations. Compared to the negative control cell line expressing the wild type human KRAS gene, all the synonymo...

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Detalles Bibliográficos
Autores principales: Waters, Andrew M., Bagni, Rachel, Portugal, Franklin, Hartley, James L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042562/
https://www.ncbi.nlm.nih.gov/pubmed/27684555
http://dx.doi.org/10.1371/journal.pone.0163272

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042562/
https://www.ncbi.nlm.nih.gov/pubmed/27684555
http://dx.doi.org/10.1371/journal.pone.0163272

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