Transient endoreplication down-regulates the kinesin-14 HSET and contributes to genomic instability

Polyploid cancer cells exhibit chromosomal instability (CIN), which is associated with tumorigenesis and therapy resistance. The mechanisms that induce polyploidy and how these mechanisms contribute to CIN are not fully understood. Here we evaluate CIN in human cells that become polyploid through an...

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Detalles Bibliográficos
Autores principales: Chen, Shengyao, Stout, Jane R., Dharmaiah, Sathiya, Yde, Sarah, Calvi, Brian R., Walczak, Claire E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042578/
https://www.ncbi.nlm.nih.gov/pubmed/27489338
http://dx.doi.org/10.1091/mbc.E16-03-0159

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042578/
https://www.ncbi.nlm.nih.gov/pubmed/27489338
http://dx.doi.org/10.1091/mbc.E16-03-0159

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